Esther Gaylene Abair was killed around 3:15 a.m. when her Honda Civic crashed with a Chevrolet Malibu driven by 21-year-old Ivette Maldonado at the intersection of Harris and Old River roads.
Maldonado wasn't injured, police said. Neither car had passengers.
Police haven't said whose at fault in the crash. They said they don't suspect the involvement of drugs or alcohol.
The intersection remained closed into midmorning.